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SBF presents "Beneath the Surface"

New monthly webinar series covering tissue engineering, biomaterials, biocompatibility, and other topics related to the tissue-material interface.
January 18, 2011
by Steve
0 Comment
biomaterial, biomedical engineering, colorado state university, digital pathology, Dr. Robert Kellar, new imaging, northern arizona university, quantitative analysis, synthetic materials, tissue engineering, webinar

Quantitating Elastic Fibers in Pig Aorta

This example came from healthy porcine aorta that was stained with Hematoxylin and Eosin (H&E). Using an area-based algorithm, we can quantitatively evaluate the sample for elastin percentage. Elastin is a critical component of the microstructure within large arteries such as the
February 27, 2010
by Rob
0 Comment
aorta, biocompatibility, cardiovascular, dermatology, digital pathology, elastic fibers, image analysis, medical devices

Brown fat measurement

We receive frequent requests for measuring brown fat. Below are some examples, with the same Flagship fat algorithm that was used previously for white fat and lung alveoli.  
February 22, 2010
by Trevor
0 Comment
brown fat, digital pathology, fat, image analysis

White fat measurement

White fat measurement is shown below with a Flagship algorithm that first segments and then individually identifies each fat vacuole. Statistics of area and perimeter per vacuole are counted, and histograms can be output as required. Some results are shown below. In areas where vacuol
February 22, 2010
by Trevor
0 Comment
digital pathology, fat, image analysis, object quantification, white fat

Measuring myocardial fibrosis in a mouse

Below is a cross section of mouse heart stained with sirius red which stains positively for fibrosis.  Interwoven trabeculae of positively staining fibrous connective tissue (see insert) are visible within the ventricular myocardium as a result of  experimental damage.  With this mous
January 22, 2010
by Frank
0 Comment
area quantification, cardiology, fibrosis, heart, vascularization

Measuring plaque in heart tissue

Histology pattern recognition could be used to identify and measure the area of necrotic core, foam cells and heart tissue versus media in rodent preclinical cardiovascular samples.
January 07, 2010
by Trevor
1 Comment
area quantification, cardiology, heart, medical devices

Automated quantification of pacemaker lead tissue changes

The need to identify tissues in a artery cross-section is very common in pathology review in medical devices. Below is an example using histology pattern recognition, where the computer has been trained to recognize the different layers.
January 07, 2010
by Rob
0 Comment
cardiology, heart, medical devices

Revascularization measurements in a cardiac patch

A scaffold-based, three-dimensional, human dermal fibroblast culture (3DFC) was used as a cardiac patcha to stimulate revascularization and preserve left ventricular (LV) function of the infarcted LV in severe combined immunodeficient (SCID) mice. The histopathology image above illust
January 07, 2010
by Rob
0 Comment
angiogenesis, cardiology, heart, medical devices, microvessel, vascularization
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