Analysis of fibrous capsules is a common procedure in evaluation of coated devices. Microvessel analysis was tested for use in identifying the fibrous capsule differences between a novel coating and a control polypropylene in a subcutaneous rodent implant model.
Microvessel algorithm was modified to detect the fibrous capsule, as shown below.
In this example, as in almost all image analysis problems, the goal is to get from images to data. Below is some example output, there clearly is a measurable difference in fibrous capsule area between the new biosurface and the control. More samples would be required to access statistical significance.