Developing a useful animal model to learn about the pathology of Alzheimer’s disease is valuable in developing potential treatments that might successfully treat this debilitating and tragic disease. Transgenic mouse models currently exist which manifest the signs and symptoms of Alzheimer’s disease. These signs include age-related memory and learning impairment associated with brain cell loss, deposition of amyloid protein and neurofibrillary tangles composed of tau protein.
In the images below image analysis was first used as a preprocessing tool to spatially segregate the core component of each amyloid plaque, thus allowing subsequent quantitation of plaque numbers, mean plaque size and total plaque percent area across entire tissue cross-sections of mouse brain.
Immunohistochemistry Section of Mouse Brain Illustrating Amyloid Plaques
Mark-up Image Depicting Amyloid Plaques