Sources of errors in IHC

If there is one image analysis question we hate, it is, “Can you perform image analysis on this badly overstained slide?”. The answer is frequently “No”.   Although in some circumstances, image analysis can overcome issues of overstaining , nonspecific staining or just plain bad histology, there are definite limits.  These issues usually greatly dimish the accuracy […]

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Histology pattern recognition -- zoom out!

Experienced pathologists are very good at using minimum magnification to look at a slide. A pathologist can see more scanning an entire slide at 5x and then occasionally jumping to 20x or 40x in a couple of areas, than starting out at 40x. We all know this, and take it for granted as pathologists. However, […]

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Oct 2009

The first digital pathology services company formed by pathologists to serve the needs of drug and device development Boulder, CO – October 9, 2009 – Flagship Biosciences LLC,(Flagship) was created as a new company entity by two experienced pathologists to leverage the use of emerging digital pathology technology. Whole slide imaging allows a pathologist to […]

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Fibrous capsule measurement for coated devices

Analysis of fibrous capsules is a common procedure in evaluation of coated devices.  Microvessel analysis was tested for use in identifying the fibrous capsule differences between a novel coating and a control polypropylene in a subcutaneous rodent implant model.     Microvessel algorithm was modified to detect the fibrous capsule, as shown below. In this […]

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