Presentations

Multiplexing IHC in Regulated Environments

Presenters: David Young
Event: Pathology Visions 2010

Voelker – Practical approaches to xenograft analysis

Presenters: Frank Voelker
Event: Pathology Visions 2010

Measuring Fat and Vacuolar Space with Digital Pathology

Presenters: Frank Voelker
Event: Aperio Webinar

Quantitation with Whole Section Analysis – Xenograft Models in Oncology Drug Development

Presenters: David Young
Conference: Japanese Society of Toxicologic Pathology 2010

Image analysis in pharmaceutical drug development (Genie overview) (Genie step-by-step)

Presenters: Frank Voelker & David Young
Conference: Pathology Visions, November 2009, San Diego, California|
ABSTRACT: Whole tissue analysis provides the ability to analyze a much larger sample size than previous image analysis approaches. However, it requires a pathologist to regularly use the quantitative tools and consistently apply them in their pathology practice. This workshop discusses what two experienced pathologists have learned by regular, daily use of histology pattern recognition and quantitation in their studies. Key concepts include: image resolution tradeoffs for analysis, sample size sets for pattern recognition, single training solutions versus multiple, workflow between pathologists and researchers, choice of cell/area/object classification. Examples from mouse xenografts, epithelial-mesenchymal transition (EMT) biomarkers, angiongenesis, diabetes, and classic toxicologic pathology will be used to illustrate these concepts.

Quantitative assessment of tissue based biomarkers in clinical studies

Presenters: David Young
Conference: Next Generation Pharmaceuticals 2009|
ABSTRACT: Clinical trials in oncology requires more reproducible accurate measurement of tissue biomarkers. In this presentation, examples from both research and clinical trials demonstrate the utility of digital pathology in making quantitative assessements in tissue. Traditional evaluation is compared with computer assisted scoring for two biomarkers: E-Cadherin, a membrane protein marker of epithelial phenotype, and Vimentin, a cytoplasmin protein biomarker of mesenchymal phenotype associated with the cellular skeleton. Examples from non-small cell lung cancer and pancreatic cancer clearly demonstrate that image analysis correlates well with pathologist assessment and removes pathologist-to-pathologist variability.

Image Analysis with Digital Pathology in Toxicology

Presenters: Frank Voelker
Conference: Invited Presentation: NIEHS
ABSTRACT: Industry and regulatory groups are increasingly requiring more quantitative observations from their toxicologic pathologists. This talk introduces pathologists to the concepts of image analysis across whole tissue sections. Examples are provided in common toxicology lesion measurement, in discovery biology, and in cancer biomarkers

Cardiac Repair Using Regenerative Medicine

Presenters: Rob Kellar
Conference: Invited Presentation: Northern Arizona University
OUTLINE:

1. Cardiac Damage

2. Pharmacology treatment– “drug-based approach“ GM-CSF antibody

3. Device treatment – “device-based approach” Extracellular matrix

4. Cell treatment – “biology-based approach”

Cardiac Patch – Anginera

Contractile co-cultured constructs