Quantification of proliferating nuclei with multiplexed IHC in between melanoma and melanocytic nevi.

New approach combining laser capture micro-dissection with digital pathology and histology pattern recognition

The eye serves as an important organ for toxicology research. Below is a rodent H&E ocular cross-section, followed by pathologist-trained pattern recognition of each layer. This provides a larger and faster region of interest drawing than would be used with manual ROI drawing by a

There are  many times when a pathologist needs to randomly sample tissue in a directed manner.  This is to assure that similar tissue substructures are sampled in a manner that prevents biasing of results.  If the problem was as straightforward as sampling ANY area, then random sampli

Detecting glomeruli is an important first step in a number of image analysis applications in renal health and toxicology. Unfortunately, it is one of the hardest applications for histology pattern recognition. In this post, I will discuss a reallife example of the steps used to do his

Experienced pathologists are very good at using minimum magnification to look at a slide. A pathologist can see more scanning an entire slide at 5x and then occasionally jumping to 20x or 40x in a couple of areas, than starting out at 40x. We all know this, and take it for granted as