Quantitative dermatopathology is just scratching the surface with digital pathology

Anti-kappa and anti-lambda detect surface light chain immunoglobulins on normal and neoplastic B-cells in human lymphoid tissue.  In normal lymphoid tissue the kappa and lambda cell ratio is approximately 2:1, but values in excess of that ratio indicate monoclonality caused by either

Quantification of proliferating nuclei with multiplexed IHC in between melanoma and melanocytic nevi.