In vitro image analysis is an important component to many therapeutic and toxicologic investigations in ocular pathology. Due to its unique geometry, the eye presents special challenges in image analysis, in either flat mount retinas or histology cross-sections.
Measurements include:
- Abnormal blood vessel formation from choroidal neovascularization (CNV) in wet atrophic macular degeneration (AMD) research
- Microaneurysm measurement in mild non-proliferative retinopathy
- Angiogenesis and abnormal vascularization in measurements in proliferative retinopathy.
- Nerve degeneration assessment and photoreceptor cell apoptosis in retinitis pigmentosa
- Gene (ISH) or Protein (IHC) expression measurement in numerous disease research areas
- Retinal ganglion cell counting in glaucoma research
- Morphological changes in cell density or retinal cell layer geometry as a indicator of toxicity.
Some examples of whole section analysis in ophthalmology are shown below in our image analysis examples and blog. Please contact us for your specific application. All of our ocular pathology services involve histology QA, whole slide scanning, quantitative image analysis, pathologist review and report. Our pathologists are happy to discuss your particular application with you.
Measuring ocular toxicologic changes with pattern recognition