The liver is the most heavily studied organ in toxicology at pharmaceutical companies, for very good reason.
There are a large number of image analysis applications that we have tried in the liver, and we will try to post them as this site develops. If you have a good liver lesion archive set, we would very much like to add to our collection, so please contact us.
Measuring bile duct hyperplasia
Bile duct hyperplasia and periportal inflammation are examples of histopathologic change in which
histology pattern recognition can assist in providing quantitative analysis for assessing the effect of a test
compound or drug.
Hyperplastic Bile Ducts (Green) Hepatic parenchyma (Red), Periportal Inflammatory Cells (Blue) Periductal Collagen (Brown), Bile Duct & Sinusoidal Lumena (Yellow)
Hyperplasia (green area) versus normal section (red area), with bile ducts (blue) excluded from the measurement, The hyperplasia area can be easily measured for a quantitative analysis of toxicity.
We will be adding a lot more posts on liver and toxicity. Veterinary pathologists can never get too much of liver, except when it is for dinner.