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Comparison of Multiplexed Imaging Mass Cytometry with Monoplex Immunohistochemistry in FFPE Tissue

Comparison of Multiplexed Imaging Mass Cytometry with Monoplex Immunohistochemistry in FFPE Tissue

by Rachel Blake | Apr 17, 2018 | Publications / Posters

Abstract Multiplexed analysis of limited tissue samples can improve our understanding of tumor biology and the tumor microenvironment. Chromogenic and fluorescent multiplexed immunohistochemistry (IHC) approaches are available and offer great insights while conserving...
Computational Analysis of Multiplexed Immunohistochemistry for Understanding Immune Profiles in Clinical Biopsy Samples

Computational Analysis of Multiplexed Immunohistochemistry for Understanding Immune Profiles in Clinical Biopsy Samples

by Rachel Blake | Apr 16, 2018 | Publications / Posters

Abstract Using immunohistochemistry (IHC) to examine immune infiltrates in tissue biopsy samples to support exploratory investigations for immuno-oncology drug development is critical for understanding the abundance and spatial relationships of different immune cell...
Analysis of Multiplexed Immunotherapy Targets and Secreted Ligands Using Computational Tumor Microenvironment Profiling

Analysis of Multiplexed Immunotherapy Targets and Secreted Ligands Using Computational Tumor Microenvironment Profiling

by Rachel Blake | Apr 16, 2018 | Publications / Posters

Key takeaways The RNAscope® platform enabled duplex chromogenic in situ hybridization (CISH) assay visualization of mRNA targets from multiple cell types and biomarkers Quantification of individual and dual cell positivity within tissue compartments Spatial biology...

The Well-Designed Study: How Validated Biomarker Measurements are Supporting Clinical Endpoints

by Rachel Blake | Oct 29, 2017 | News

It is no secret that drug developers are under increasing pressure to discover new targeted therapies to meet high unmet medical needs, and to design clinical trials that will minimize the risk of failure to gain commercial approval. As research on diseases like...

Sarepta Enters into Partnership with Flagship Biosciences in Muscular Dystrophy

by Rachel Blake | Aug 21, 2014 | News

New technology designed to speed dystrophin measurement while ensuring consistency Automation of dystrophin measurement will aid development of Sarepta’s Duchenne muscular dystrophy candidates Cambridge, Mass. – Aug 20, 2014 – Sarepta Therapeutics, Inc, a...
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