Characterizing the Heterogeneity of CD8 Inflammation in Biopsied Tumor Tissues Using Novel Image Analysis Techniques (Poster No. 3137 #AACR2021 in partnership with Scholar Rock)

Key takeaways

  • An image analysis-based algorithm was used to assess CD8 expression in numerous tumor nests in non-small cell lung cancer, bladder, and melanoma tumor samples
  • Measuring CD8 expression within tumor nests rather than averaging across a whole tissue section provided a more informative assessment of inflammation
  • Identifying specific tumor areas of concern for further investigation can help inform the mechanisms for drug efficacy or resistance