Methodology for Designing and Validating Computational Pathology Scores for Immune Cell Clustering in Tumor Biopsy Samples
Key takeaways Understanding the frequency and nature of immune cell clustering is useful in determining patient responses to immunomodulating therapies Flagship’s unique spatial biology services
Comparison of Multiplexed Imaging Mass Cytometry with Monoplex Immunohistochemistry in FFPE Tissue
Abstract Multiplexed analysis of limited tissue samples can improve our understanding of tumor biology and the tumor microenvironment. Chromogenic and fluorescent multiplexed immunohistochemistry (IHC) approaches
Analysis of Multiplexed Immunotherapy Targets and Secreted Ligands Using Computational Tumor Microenvironment Profiling
Key takeaways The RNAscope® platform enabled duplex chromogenic in situ hybridization (CISH) assay visualization of mRNA targets from multiple cell types and biomarkers Quantification of
Computational Analysis of Multiplexed Immunohistochemistry for Understanding Immune Profiles in Clinical Biopsy Samples
Abstract Using immunohistochemistry (IHC) to examine immune infiltrates in tissue biopsy samples to support exploratory investigations for immuno-oncology drug development is critical for understanding the
CASE STUDY: Multiplex Assays with Coregistration Enables Multiple Biomarker Analyses Across Tissue Sections
Summit Therapeutics, a life sciences company developing a therapy for Duchenne muscular dystrophy (DMD), was faced with a drug development challenge. They needed to accurately
WHITE PAPER: Getting the Whole Picture for Immuno-Oncology Therapies
Key Concepts: Immuno-oncology (IO) therapies have changed the way we think about patient selection for precision medicine. The complexity of tumor/immune interactions creates an opportunity
