Key Concepts: While the current diagnostic strategies for PD-L1 checkpoint inhibitors identify some responders well, the majority of patients still need diagnostic approaches that better predict response. PD-L1 IHC remains a valuable tool for predicting patient...
Publications / Posters
Methodology for Designing and Validating Computational Pathology Scores for Immune Cell Clustering in Tumor Biopsy Samples
Key takeaways Understanding the frequency and nature of immune cell clustering is useful in determining patient responses to immunomodulating therapies Flagship’s unique spatial biology services generated a validated computational pathology score that characterized...
Comparison of Multiplexed Imaging Mass Cytometry with Monoplex Immunohistochemistry in FFPE Tissue
Abstract Multiplexed analysis of limited tissue samples can improve our understanding of tumor biology and the tumor microenvironment. Chromogenic and fluorescent multiplexed immunohistochemistry (IHC) approaches are available and offer great insights while conserving...
Computational Analysis of Multiplexed Immunohistochemistry for Understanding Immune Profiles in Clinical Biopsy Samples
Abstract Using immunohistochemistry (IHC) to examine immune infiltrates in tissue biopsy samples to support exploratory investigations for immuno-oncology drug development is critical for understanding the abundance and spatial relationships of different immune cell...
Analysis of Multiplexed Immunotherapy Targets and Secreted Ligands Using Computational Tumor Microenvironment Profiling
Key takeaways The RNAscope® platform enabled duplex chromogenic in situ hybridization (CISH) assay visualization of mRNA targets from multiple cell types and biomarkers Quantification of individual and dual cell positivity within tissue compartments Spatial biology...
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Recent Posts
NEWS
Flagship Spotlight: Roberto Gianani, MD
Introduction and BackgroundDr. Roberto Gianani, Chief Medical Officer at Flagship Biosciences, Inc., is a practicing pathologist who is board certified in anatomic pathology, clinical pathology, and pediatric pathology. He is fellowship-trained in surgical pathology...
Flagship Spotlight: Adam Beharry
Introduction and BackgroundAdam Beharry, PhD, is a Flagship scientist who describes his work as applying advanced technical knowledge and critical thinking to expand Flagship’s tissue image analysis in neuromuscular and rare diseases. Adam’s degrees include: BS –...
White Paper: Tissue Image Analysis and Biomarker Assessment Implementation Benefits and ROI
IntroductionThe success of clinical trials is highly dependent on the intricacies of patient recruitment. Other challenges, from the costs of clinical supplies to the specific procedural requirements that can extend physicians’ time, can increase costs. There are also...
EVENTS
Utilizing RNAscope in the clinic: Why you need image analysis to handle the complexity
Utilizing RNAscope in the clinic to handle complex analysis. RNAscope is rapidly becoming a solution for understanding complex biomarker challenges. The benefits and awareness of image analysis in the space of pathology have been widely discussed and rapidly growing....
Precision Patient Care: Seamless Optimization of Diagnoses, Companion Testing and Therapy Design
Technology Leads the Way to Precision Patient Care Digital transformation comes in many flavors. In pathology, it can be as simple as merely scanning pathology slides into whole slide images. However, it can also represent end-to-end digital pathology workflow...
Pathology Visions 2021
Pathology Visions 2021October 17-19, 2021Digital Pathology: The Future is Here is the theme of this year’s Digital Pathology Association annual conference, Pathology Visions 2021. #PathVisions21 featured a poster from Flagship’s CCO Meredith James on a novel approach...