Key Concepts: While the current diagnostic strategies for PD-L1 checkpoint inhibitors identify some responders well, the majority of patients still need diagnostic approaches that better predict response. PD-L1 IHC remains a valuable tool for predicting patient...
Key takeaways Understanding the frequency and nature of immune cell clustering is useful in determining patient responses to immunomodulating therapies Flagship’s unique spatial biology services generated a validated computational pathology score that characterized...
Abstract Multiplexed analysis of limited tissue samples can improve our understanding of tumor biology and the tumor microenvironment. Chromogenic and fluorescent multiplexed immunohistochemistry (IHC) approaches are available and offer great insights while conserving...
Abstract Using immunohistochemistry (IHC) to examine immune infiltrates in tissue biopsy samples to support exploratory investigations for immuno-oncology drug development is critical for understanding the abundance and spatial relationships of different immune cell...
Key takeaways The RNAscope® platform enabled duplex chromogenic in situ hybridization (CISH) assay visualization of mRNA targets from multiple cell types and biomarkers Quantification of individual and dual cell positivity within tissue compartments Spatial biology...
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NEWS
Introduction and BackgroundDr. Roberto Gianani, Chief Medical Officer at Flagship Biosciences, Inc., is a practicing pathologist who is board certified in anatomic pathology, clinical pathology, and pediatric pathology. He is fellowship-trained in surgical pathology...
Introduction and BackgroundAdam Beharry, PhD, is a Flagship scientist who describes his work as applying advanced technical knowledge and critical thinking to expand Flagship’s tissue image analysis in neuromuscular and rare diseases. Adam’s degrees include: BS –...
IntroductionThe success of clinical trials is highly dependent on the intricacies of patient recruitment. Other challenges, from the costs of clinical supplies to the specific procedural requirements that can extend physicians’ time, can increase costs. There are also...
EVENTS
Utilizing RNAscope in the clinic to handle complex analysis. RNAscope is rapidly becoming a solution for understanding complex biomarker challenges. The benefits and awareness of image analysis in the space of pathology have been widely discussed and rapidly growing....
Technology Leads the Way to Precision Patient Care Digital transformation comes in many flavors. In pathology, it can be as simple as merely scanning pathology slides into whole slide images. However, it can also represent end-to-end digital pathology workflow...
Pathology Visions 2021October 17-19, 2021Digital Pathology: The Future is Here is the theme of this year’s Digital Pathology Association annual conference, Pathology Visions 2021. #PathVisions21 featured a poster from Flagship’s CCO Meredith James on a novel approach...